Crypto portfolio companies represent the most innovative blockchain startups, backed by leading venture capital funds and accelerators. These projects are shaping the future of DeFi, NFTs, infrastructure, and Web3 ecosystems, driving adoption and pushing the boundaries of what’s possible.

Explore the top portfolio companies of 2025 funded by renowned VCs like a16z, Paradigm, and Pantera Capital, and discover the projects leading blockchain innovation.

Building a high-performance, EVM-compatible Layer 1 blockchain with 10,000 TPS and single-slot finality.

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Transactions Per Second

10,000 TPS

Finality Time

1 Second

Empowering open innovation through protocols like EigenLayer and EigenDA, enhancing Ethereum's scalability and security.

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Key Protocols

EigenLayer, EigenDA

Mission

Empower Open Innovation

Creating a decentralized AI blockchain platform for collaborative development and monetization of AI assets.

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Core Concept

AI Assets

Platform Focus

Decentralized AI Development

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Leading Crypto Portfolio Companies Backed by VCs

Monad Labs Overview

Monad Labs is a next-generation blockchain infrastructure company that is pioneering high-performance Layer 1 solutions for decentralized applications. The project focuses on delivering unmatched speed and efficiency with full compatibility for Ethereum Virtual Machine (EVM) applications. By combining parallel execution with pipelined consensus, Monad is able to achieve 10,000 transactions per second and single-slot finality—bringing scalability without sacrificing security or decentralization.

Monad's architecture makes it easy for developers to port over existing Ethereum-based dApps without rewriting smart contracts. This allows for seamless transitions and fast deployment of DeFi protocols, NFT marketplaces, and other Web3 applications, while offering end-users significantly lower gas fees and faster confirmation times.

With its advanced execution engine and innovative consensus mechanism, Monad Labs is positioning itself as a competitive alternative to other Layer 1s while preserving Ethereum compatibility. The team consists of seasoned engineers and crypto-native builders committed to solving the blockchain trilemma of scalability, security, and decentralization.

As adoption grows, Monad could become a core platform in the broader Web3 stack—delivering the speed and performance needed for the next wave of decentralized apps and services.

Perks

High throughput and low-latency transactions.

Full compatibility with Ethereum's EVM.

Optimized for decentralized applications and DeFi platforms.

Transactions Per Second

10,000 TPS

Finality Time

1 Second

Welcome bonus

Building a high-performance, EVM-compatible Layer 1 blockchain with 10,000 TPS and single-slot finality.

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Eigen Labs Overview

Eigen Labs is the creator behind EigenLayer and EigenDA, two powerful protocols designed to enhance the scalability and security of Ethereum and other decentralized networks. Through the concept of restaking, EigenLayer enables users to reuse their ETH staking collateral to secure additional protocols, driving capital efficiency and composability in the Ethereum ecosystem.

The company’s second innovation, EigenDA (Data Availability), improves on-chain data availability by allowing rollups and Layer 2 protocols to publish their data on a decentralized network with strong guarantees. This increases throughput and scalability while minimizing trust assumptions.

Eigen Labs is focused on promoting open innovation through modular blockchain components. Its technology stack provides developers with the tools needed to build decentralized services more efficiently while maintaining Ethereum’s security guarantees. The team collaborates closely with the Ethereum research community and has attracted strong interest from the broader DeFi and rollup ecosystem.

By advancing modularity and enabling new economic models in crypto infrastructure, Eigen Labs is shaping the future of Ethereum scalability and empowering developers to build more powerful decentralized applications.

Perks

Development of cutting-edge Ethereum scalability solutions.

Focus on open-source research and community collaboration.

Contributions to enhancing blockchain infrastructure security.

Key Protocols

EigenLayer, EigenDA

Mission

Empower Open Innovation

Welcome bonus

Empowering open innovation through protocols like EigenLayer and EigenDA, enhancing Ethereum's scalability and security.

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Sahara AI Overview

Sahara AI is building a decentralized infrastructure for artificial intelligence development, data sharing, and monetization. The platform empowers users to contribute and profit from AI models and datasets through tokenized ownership and decentralized governance. By operating on-chain, Sahara provides transparency and immutability—enabling fair and open collaboration for AI innovators.

One of Sahara AI’s most innovative concepts is that of “AI Assets,” which formalize the ownership of datasets and algorithms. These assets can be licensed, monetized, or improved collaboratively, creating a dynamic ecosystem where developers, researchers, and contributors are fairly rewarded for their efforts.

Sahara is also committed to privacy and ethical AI use. It leverages blockchain to enforce user consent and data sovereignty, ensuring that contributors retain control over how their data and models are used. This is particularly important in industries like healthcare, finance, and social media, where data privacy is paramount.

With a strong emphasis on decentralization, interoperability, and transparent incentive mechanisms, Sahara AI is at the frontier of the decentralized AI revolution—bridging the gap between Web3 infrastructure and artificial intelligence innovation.

Perks

Decentralized platform for AI development and monetization.

Emphasis on data privacy and ownership rights.

Collaborative environment fostering innovation in AI.

Core Concept

AI Assets

Platform Focus

Decentralized AI Development

Welcome bonus

Creating a decentralized AI blockchain platform for collaborative development and monetization of AI assets.

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What Are Crypto Portfolio Companies?

Portfolio companies are blockchain startups that have received funding from venture capital firms, incubators, or accelerators. These companies often represent the cutting edge of innovation in crypto and Web3.

Key Features:

VC Backed – Supported by established crypto venture firms.
Scalable Innovations – Building solutions in DeFi, NFTs, infrastructure, and more.
Market Validation – Selected for their potential impact and growth.
Ecosystem Leadership – Often driving trends and adoption in their sectors.

Top Crypto Portfolio Companies [2025]

Project	Sector	Backers	Visit
Uniswap	DeFi (DEX)	a16z, Paradigm	Visit
Polygon	Layer 2 scaling	Sequoia, Binance Labs	Visit
dYdX	DeFi derivatives	Paradigm, a16z	Visit
The Sandbox	Gaming, metaverse	Animoca Brands, SoftBank	Visit
Axie Infinity	Gaming, NFTs	Delphi Digital, a16z	Visit
Lido Finance	Liquid staking	Paradigm, Dragonfly Capital	Visit
Helium	DePIN (IoT)	Multicoin Capital, a16z	Visit
LayerZero	Cross-chain infrastructure	Sequoia, a16z	Visit
Avalanche	Layer 1 blockchain	Polychain Capital, Three Arrows	Visit
Optimism	Layer 2 scaling	Paradigm, a16z	Visit

These portfolio companies are leaders in blockchain innovation and adoption.

Sectors of Focus for Portfolio Companies

DeFi (Decentralized Finance) – DEXs, lending platforms, derivatives.
NFTs & Gaming – Metaverse assets, marketplaces, play-to-earn ecosystems.
Blockchain Infrastructure – Layer 1, Layer 2, cross-chain bridges, oracles.
DePIN (Decentralized Physical Infrastructure Networks) – IoT, telecom, energy grids.
Staking & Liquid Staking – Yield-bearing solutions for PoS blockchains.
DAOs & Governance – Decentralized decision-making platforms.

These sectors are driving blockchain’s evolution in 2025.

How Portfolio Companies Shape Crypto

Lead in Adoption – Bring blockchain solutions to mainstream users.
Drive Innovation – Introduce novel financial products, scalability solutions, and user experiences.
Expand Ecosystems – Create tools and platforms that attract developers and users.
Set Industry Standards – Influence best practices, compliance, and security in crypto.
Fuel Web3 Growth – Power the decentralized economy of the future.

Portfolio companies are the front-runners in blockchain innovation.

How to Connect with Portfolio Companies

Follow Their Roadmaps – Stay informed about their milestones and developments.
Join Communities – Engage with their governance, Discords, and forums.
Explore Integrations – Use their tools, dApps, or participate in their ecosystems.
Attend Events – Meet founders and teams at crypto conferences and online sessions.
Invest or Stake – Support projects by participating in their token economies.

Conclusion – Meet the Innovators of Blockchain

Crypto portfolio companies are pioneers shaping the next generation of Web3. Backed by top VCs, these startups lead the charge in driving real-world adoption and technological breakthroughs.